Energy.....oh boy.
JWP mentioned the inefficiency of the .460 because the cartridge is rather inefficient. With normal weight bullets, loaded to max SAAMI pressures, the .454 Casull, with it's small case (1.4 vs 1.8-inches) will nearly keep up with it. It's only when you go really light or really heavy that the .460's extra payload capacity gives it an advantage. It's just not terribly efficient. It's length necessitates a revolver with rather portly dimensions. You shoot game out to 200 yards with a .454 as well, but you may not need a bipod and a gun bearer.
But, whatever gets you through the night........