If you click, you must be sure your sight is repeatable. And on ones that have slop, a helpful hint is to go past any correction by 10 clicks and then come back. helps take the slop out.
Personally with iron sights, my front sight is flat topped, not a round blob. I zero at 100 yards with the bullet hitting X inches high(you fill in the blank to fit the top of the heart) and if lucky at 100 I hold bottom of the brisket which is very easy to delineate. Hold bottom, hit heart or lungs. Go out further and I simply learn at XXX yards hold mid body, XXX hold back line, or up close say 50 yards, I"m usually still just fine, hold the bottom or a bit of "air" and good to go.
Then just make a small diagram, yardages, and holds, a bit of wind info IE 15mph info usually, and seal it and tape to the stock.
Range is the one that will tell you. In fact this year I probably won't even shoot over the chrono as I take accuracy over speed most days.
And I'm a firm believer that if you intend to shoot at a specific distance, you have to fire at that distance.
AND since I"m way away from my hunt and about 10K feet lower, I"ll be checking my sights at altitude before arriving in the hunting area. Have seen CO mess with a TX zero before.
Jeff