Thus is second-hand, but my sons took 3 deer last year with my Knight using 300gr .45 Hornady XTPs, the regular ones, not mags, over 80gr (56 gr by weight) BH 209. The light load keeps the bullets within the velocity window for good perfomance. All three were pass-throughs with big exit holes, including one on a 200+ pounder. Blood trails were short, the best kind.
