Obviously, I've never had the privilege to hunt the speed goats but....
if the opportunity presented itself I would use one of my trusty 270s but...
that just might be excuse for me to get a 25-06. The 25-06 has had many great revues for antelope hunting for a l o n g -time. With its medium size bullets, streaking fast, and flat trajectory, it is hard to beat.
It can be beat by larger cartridges, more powder, bigger/heavier bullets but they're NOT needed.
Jerry