I've not shot a rifle that hurt me yet but I've not fired any of the REALLY big boys. 416 Weatherby is as high up the food chain as I've gone and that never from a bench. Kinda fun actually.

With pistols I've shot plenty of .500 S&W but two consecutive cylinders of the heavy/full power loads is about all I'm good for before accuracy starts dropping off.

If there's one thing I've become certain of it's that there's too much certainty in the world.