Bullet selection has much to do with meat damage. The various common factory loads for a .450 all come with relatively soft bullets and exacerbate tissue destruction due. Same shot with a 400ish grain hard cast lead likely produces much less tissue damage.
I often hunt with TSXs for just this reason, minimal tissue damage. However I know that to get radical terminal effects I need to shoot substantial bones. Bang flops, that aren't CNS hits, are more common with softer bullets with greatly increased tissue/meat damage.
