I haven't burned up my first pound of 4451 yet, but I have tried it in my iron sighted Rem 760, .257 Bob, and my custom .280.
It shot the best groups I've ever gotten with the 80 gr. Barnes TTSX or any other bullet for that matter in the 760.
In the .280, It works very well with Barnes's 145 gr. LRX, something Ramshot's Hunter couldn't even remotely do, and shot quite well, at the same powder charges as H4350, with the Barnes 120 gr. TTSX.
My impression is that it meters better than H4350, and alot better than IMR 4350. E