Speaking of 375's, I've been having fun filing my new single blade express rear sight in on my Rube Goldberg 375 AI, the 300 gr BBW#13 solids are dead on zero at an easy 2750 fps, the 270 gr TSX's at 3000 fps are striking dead on 3" high at 100 through the 2.5-8 Leupold in QD Talleys.
That combo would work well anytime, anywhere, and on any animal.
