Formid,
You bring up some interesting points and have proof to back them up.
I cant disagree, one question though you refer to approximately 20" of penetration. Do you believe that's enough for larger critters like elk?
I read on a previous post you were considering a 243 for an elk hunt?
And you posted a pic of you? in Glacier close to a grizzly with a Glock 9mm.
We know 458win mag(Phil) stopped a charging grizzly with a 9mm.
With new bullet technology maybe we should rethink the old norms?
That being said, I shot a small whitetail at close range with a 22 Hornet, tight behind the shoulder in the lungs. The load was a 50gr Hornady at 2300fps, it ran off and I never found it, made me sick thinking about it.
Point being you can go too far with the marginally powered rounds.
I suspect Alaska Lanche would feel a little uneasy prowling around Alaska with a 22-250, I know I would.