I shot one deer with the 223. Small buck, 45gr TSX. Hit rib going in and out. Lodged under skin on off side. Deer went about 50 yards. Lungs pretty mushed up.
I would think something heavier would be better choice for deer.
My #3 likes 40 and 45 grainers, so that is what I used and I will reserve it for varmints in the future.
jmho
Tim