When I went caribou hunting in western AK, I carried a 340 Wby because the grizz/ brownies were everywhere it seemed.

Now, out west, if in grizz country or wilderness areas, after game is down, I carry a S&W 329 44. Any heavier and I wouldn't carry it but it's not a handgun for the heaviest, hardcast loads either because of the recoil and possibly bullets walking forward in the cylinder under recoil and potentially locking it up. I haven't experienced that personally but read of it.