I use my 375 H&H out past 300 yards. Not often, but I have. And with Remington green box ordinary Coreloks. Scope was a Swarovski 3-12x50 30mmtube in Leopold QR not QRW. They work great. That was Namibia for kudu and gemsbok. I used such a big bell for last light leopard shooting. I won't shoot a leopard at night with a light. Then could put my backup old Red field 3-9 on if need be. So if a H&H with crappy Coreloks can do 300 plus yards, a 375 Ruger should be no problem as I have heard they shoot a touch flatter than the H&H. I am gonna try those 200 grain he's talking about as soon as I get a chance. I just moved and want to do my reloading bench very proper.