We always used the Garret loads when we had 45-70s as our fishing guns in Alaska. Never needed it but a buddy used his on five moose and three bear two blackies and one Grizzly and it worked fine. Factory 405s did too forgot what other loads were used. In general the softest bullet that will still penetrate enough is the fastest killer. But at 45 caliber I consider them to be partially expanded to begin with.

"When you disarm the people, you commence to offend them and show that you distrust them either through cowardice or lack of confidence, and both of these opinions generate hatred." Niccolo Machiavelli