Tell you... I've shot the 458 Win Mag and the 450 Ackley.
Shot 'em okay - but I have to admit that's one level above what I enjoy shooting!
I enjoy shooting my 375, and shoot it well. But those doggone 45 cal rifles slinging 500 gr bullets... That's a step beyond my comfort zone.
Much respect for those who shoot 'em well and enjoy it.
Guy