There ain't a nickels worth of difference between most anything from the .243 up to the .338, giving good bullets and proper shot placement.
I think that statement is the most accurate one made since this thread turned into a debate. A guy hunting with a 300WM cant tell a guy that has killed 30 elk and 30 mule deer in his lifetime with a 25-06 that he doesn't have the right gun for hunting the west. On the flip side a guy hunting with a 25-06 cant turn to a guy who has killed 30 elk and 30 mule deer with a 300 WM and tell him that he has too much gun. They are both more than capable of filling many a freezers over a lifetime, simply choosing either one or a dozen other calibers that will work easily as well is the hardest part. There is no best, theres is only what works, and what works for each of us is quite likely different!
I used the 25-06 as an example since the 257 Roy is equal and mo betta but more specialized!...grin
