Mike: I think the 375 Ruger is the best new big game cartridge to come along in quite some time.With todays really good premiums running in the 235-250 gr weights(TSX/Aframe/Woodleighs, etc)moderate rifle weight and manageable recoil(for what you get),it would be a flexible,portable, powerful combination. Can't imagine anything better on a moose hunt in grizzly country.
With that and your STW,you can hunt the world!
Matter of fact,IIRC a guy named Warren Page did exactly that with a Mashburn and a 375 Weatherby(older versions of the same thing).Old Warren knew whereof he spoke.....