Choose a platform, and go from there.
Semi-auto = 10mm
Wheelgun = .41
Nothing you hit with either, will ever know or care about the differences.
For the most part, VAnimrod nails it right on the head. The .41 Magnum gives you more options for bullet shape, since a revolver is agnostic to bullet shape, and bullet weight. The 10mm basically tops out at 200 grains, but you may find something slightly heavier. If you want to hunt larger than deer game, the .41 mag will give you better options in heavy cast bullets like the LBT WFN�s. I doubt you�re ever going to get a 10mm bullet with a meplat as wide as a WFN, but who knows?
That's the only exception I can think of to VA's comments.
