Maybe, Kevin. The hottest pressure tested loads I can find for the 10mm run about 1150-1170 fps. with a 200 gr. bullet.
In the 41 Magnum, 210 gr. loads with slightly longer barrels run 1400-1425 fps.
As far as penetration goes, I've punched through 3 end to end 2.5 gal water jugs with Double Taps 200 gr. wide flat points in the 10. That's what the standard swagged lead loads from the .44 Magnum do. The same stuff Elmer Keith used to shoot through the frontal plates on big range bulls. Just what anyone would need more penetration for is beyond me. E