I shot a spike muley head on that way last year. He dropped straight down, because the 100gr Hornady interlock from the 250 Savage hit the spine. My second shot at my antelope buck this year was just about head on (first shot missed and hit the leg). He spun around twice and dropped. Same 250 Savage, same 100gr Hornady interlock. That one hit the lungs and the heart. 70 yards or so for the muley, 200 or so for the antelope.
