I will second my old buddy Steve (Dogzapper) on shooting facing animals a little higher than most people do. The lowest place I'd aim is the "dimple" at the bottom of the neck, which the Germans have some nifty compound name for that I can't remember right now. If you put the bullet there, or a little higher, the animal drops from a broken spine. Even if the bullet is a little off, they'll usually drop and a cut carotid or jugular will bleed them out quickly.

I've seen a bunch of animals from pronghorn to Cape buffalo dropped with a shot from the "dimple" upward.

“Montana seems to me to be what a small boy would think Texas is like from hearing Texans.”
John Steinbeck