Ruger #1 is a great rifle and the .375 H&H is a great cartridge that can do it all but I might look a bolt action rather than the #1 because it's going to kick like hell in a #1. With a 270 gr bullet @2,700 fps trajectory is similar to a 30-06 with a 180 gr bullet. I've killed buffalo, hippo, moose, antelope, etc with it and it's just a great cartridge, fantastic for elk as well. I've moved on to the .375 Weatherby just because I like to play with different cartridges but if I could only have an H&H I wouldn't be disappointed.