My .270 loves these, but I haven't had a chance to take game with them yet. I know someone who uses them in his .270 and prior to going mule deer hunting a couple years back, he tacked a target on a 12-14" pine tree to check his zero (I would prefer to shoot dirt myself, not trees). That 160 sailed right on through all that wood. A week later he connected on a nice buck at about 200 yards. He hit behind the shoulder (no bones) and the buck stubled about 20 yards and dropped. I'm sure there are a bunch of bullets that will do that, but if the 160 is the most consistently accurate in your rifle (it is for him), then I see no problem going with the slightly heavier option.