I started shooting prairie dogs in 1949 with a 22 RF rifle. Since then I have used 17 HM2, 17 HMR, 17 Fireball, 17 Rem, 204 Ruger, 22 WMR, 22 Hornet, 221 Fireball, 222 Rem, 223 Rem, 22-250 Rem, 220 Swift, 243 Win , and some big game rifles to shoot p dogs. But if I could have only one rifle , it would be chambered for the 204 Ruger. But I do have a CZ Varmint 17 Hornet rifle on order. Any small bore center fire rifle with a good scope that will shoot 1/2 inch five shot 100 yard groups is fun for shooting p dogs at 300 yards when one knows how to hold into the wind.