Minutia defines the topic, even with the 270 interjected into the topic. I have pretty decent hunting rifles proven at long range in 6x284, 6.5x284, 25x284, 270, 280AI, and some multiples of those calibers. I usually find myself with a 280Ai with 162s in my hand for no particular reason (if I am not grabbing a 243Ai). Not sure of the intangible factor that drives me to run 280AIs, probably familiarity, but something always directs my hand when I open the safe to grab my 280Ai over the other chamberings discussed in this thread and many others not not discussed.
My advice is to built several of each then just hunt with the ones you like best, they all do a remarkable job killing stuff even if you put decent bullets through vitals.
Familiarity is worth a lot more than all these silly conversations touting one among these closely comparable cartridges as markedly superior to another...in other words, I agree.
