I used the Speer 270 gr. bullets on several animals:

Impala; DRT and the bullet wasn't recovered.

Warthog; DRT and the bullet wasn't recovered.

Blesbok; DRT and the bullet wasn't recovered.

Blue Wildebeest; the bullet entered the right shoulder and came to rest under the skin on the opposite side. The animal ran about 200 yards and died. The bullet was perfectly mushroomed but there had been jacket/core separation.

Warthog; ran probably 80 yards and died and the bullet wasn't recovered.

Zebra; went probably 25 yards and died in a big pool of blood. The bullet broke up but had likely hit a branch before it hit the Zebra.

In my opinion, dead is dead and though I now used different bullets in my 375s, I wouldn't hesitate to use the Speers again.