There is nothing I've done with a rifle that I couldn't have done with a .308 Win, including my longest shot ever, a cow elk last year at nearly 500 yards.
While I don't plan to give up my 7mm RM, .300WM or .338WM, this year I'll be hunting with a a .30-06 Ruger American Dad gave me last August, for no other reason than it is still a virgin.
The older I get the more I think something like this, at a light, handy 5.75 pounds, is all I need:
http://www.ruger.com/products/HawkeyeCompact/specSheets/37139.html 
