If you look at the history of the caliber, the 22.250 just didn't have the juice capacity to get a 48 grain bullet out the tube @ 4100 fps safely or it would have been the Swift. Didn't cut the mustard. Ackley just rectified the short coming.
22.250 AI = 220 Swift.
Swifty, In my Swifts, I shot the 50's at 4000 with a charge of 44.0-44.5g of 2700 out of 26" barrels. The really nasty part of shooting a swift is case growth, trimming, full length sizing.
In the 22/250 AI, it seems to be a magic cartridge in how it takes the pressure without the need for full length sizing and case growth(forget case trimming).
In a 26" barrel, I shot the 50's at 4150 into very tiny bug holes, same with the 55's at 4050 fps, 60 & 65g at 3650-3700 fps.
There is no down side to the 22/250 AI, it is a HUGE improvement over a 220 Swift. If you love the Swift, then get an AI'd Swift!