I killed a lot of coyotes with the Ruger skeleton stock SS 22 Mag with the Winchester 40g HP.
I would like to warn you that you need the penetration and bone breaking ability of a heavier bullet.
We shot an ungodly number of p. dogs, ground squirrels, jack rabbits with the win 40g HP out of Marlin 25's and I had a very accurate mauser 210 in 22 Mag.
I considered coyotes dead at 75 yards, and beyond hits had to be perfect. My longest shot was in the 150 yard range with frontal shot with him facing me, hit him square between the legs.
I zero'd my rifles at 100 yards, 1" high at 50 yards, aimed at the top of their heads at further ranges.
You should consider that your bullet is going to have to be able to break a rib or shoulder blade.
