Forced to choose, I think I get the most satisfaction out of dropping the big 'ol 240 grain SWCs into my S&W 629. I used to use a lot of .44 special cases, but after wearing them all out, I now use .44 mag brass. Stocked up on 1,000 of Starline brass, so technically, the answer would be... .44 magnum.
I shoot them at .44 Special velocity most of the time, using 7.5 grains of Unique, but I'm almost out of it and have a can of Universal to try next.
I guess I get the satisfaction partly between the "thunk" it makes dropping it in the chambers, the mild recoil when shooting it, the resulting big holes in the target, and knowing I can always ramp up the power whenever I feel like it.
