I could narrow it down to 2. One for the revolver.
No shock to the regulars here, the .44 mag suits my needs perfectly, for rodents to big game.
The .45 ACP would be my top choice for semi auto needs.
That being said, I recognize the immense practicality of the 9mm for social and professional use.
But if forced to just two, the .44 mag and .45 ACP would work for me quite well.