Largest bloodtrail I've seen from a deer to date was with a .257 Wby Mag with 120 gr. NPs. Hunting partner was watching my shot with binos and freaking out... said he could see a thumb-sized jet of blood pumping out of the offside of the buck as he ran 40 yards and keeled over. He immediately tried (and failed) to buy my rifle...

If you're fixin' to put a hole in something,
make it a hole to remember.