I've not shot any big game with a 22 cal. I do know a thing or two about blood trails. They have more to do with shot placement than caliber, as others have mentioned. Shoot at the heart/lung juncture, and there will be blood. Shots lower in the body cavity allow leakage. Of course, the bigger the hole, the more blood can leak. My best blood trails on deer have been short (about 50 ft max), and look like a bucket sloshing. These have been with various calibers hitting in the bottom 1/3 of the ribs near the foreleg, and generally clip the top of the heart.
To summarize: it isn't the bullet, it's the shot placement.
