Another vote here for the fantastic 257Wby. For my particular hunting, which is almost always over large bean fields, my custom Pre-64 in 257Wby is ideal. Zeiss 4.5-14x50 up top with turrets gives me the option if I really want to stretch out there, but I can just hold on hair out to 400yds using a 100gr TTSX. It's definitely no lightweight, but I usually don't haul it very far anyway and the extra weight really helps me get steady for those longer shots.
Those who must raise their voice to get their point across are generally not intelligent enough to do so in any other way.