I've only used the 100 Hornady on deer, but every one I've pulled the trigger on have gone into my freezer with one shot apiece. Son-in-Law got one with the 115 Partition without drama. Cheezy got a couple with the 100 TSX and I've got some 100 BTs to try out some time. Doesn't seem to be any secrets, just put a decent bullet where it belongs.