I agree, with proper shot placement any 100 gr.+ bullet works well on deer size game. However, poop happens. I watched a buddy hit an antelope in the elbow at 125 yds.+/- with a Sierra 100 gr. SPT and fully expected that animal to tip over within sight (could see it for 200 - 300 yds. before it went over a hill) - never did recover it, bullet did not penetrate to the vitals.
After witnessing that, I recognized the value of a tougher .257 bullet. I now load the 110 Accubond for his .257 Rob. and my .257 Ackley. So far, so good, he took a nice cow elk with it the following year.