where i hunt deer are up to 200lb gutted and there is a good chance that i may see a 500-700lb bear. i like at least a 120-150gn bullet.with a chance at a once in a lifetime buck or bear i'd just as soon stay well armed. i didn't say you couldn't kill deer with a 22 caliber bullet and i have done that.but i've seen big animals lost to smaller calibers to.