I built myself a lot of rifles.
I have reamers for 25-06, 257RAI, 257R, 250 Krag Ackley, 250 Sav, and 25-35.
I also have rifles in 25-20 and pistols in 25acp.
I have shot 3 deer with the 257 Roberts Ackley Improved rimmed in an 1885 single shot with 115 gr Nos Bal Tips at 3050 fps.
One of them was the buck in the pic. It broke his shoulder. So it was bang flop, but anything but dead. He could not get up. That is the heaviest deer I have ever dealt with.