For me, I'd say the top five most overrated cartridges should have "AI" after their name.
I'd agree if you were talking only about larger caliber rounds like, say a 338-06 Improved and even the 30/06 Improved as you're not making a significant enough change to the powder capacity. On the other hand, the 243, 257 Roberts, 280 Remington and a few others do pick up some more FPS, not to mention greatly improved case life. If you don't reload, however, save your $$$$. The largest "Improvement" is case life.