a 124 HST at 1200 out penetrates a 230HST at 950 in "wood, metal, etc.??
The current best performance in FBI/LE 9mm duty pistol ammo is the latest 147 GDHP, it has been thoroughly tested, and bests the 45 +p HST in every FBI test category. It has been tested and proven in use, with the latest FBI/LE approved handgun loads, a 45acp offers no advantage to the 9mm. If forced to shoot ball, it has an advantage. FBI/LE ammo, it has no performance gain with added baggage.
There is no magic pill. Repeated center mass hits, fast and accurate, until threat stopped. Regardless skill, obtaining multiple accurate hits at speed, is easier obtain with a 9mm vs 45acp.
