Deer may be shot every day of the year with a 22lr. But their reasons for choosing it, are different than yours.

Not seeing why you want to? Just to brag about skill? Are you worried about bothering neighbors? Silencer would be nice, if legal. Added cost though. Traveling towards somebody and safety?

I wouldn't, but why not a 22 magnum, if you got one.

You got a tricked out 10/22 you want to play?