CCI Mini mag hp in the lungs if not suppressed. CCI 0074 if suppressed in lungs.
For head only, CCI Mini Mag solids.
Its all in shot placement, patience like after any shot, and ability to trail if need be.
22s will kill deer just fine. Its almost all I use for hogs up to about 250 for the last few years. In fact have been shooting them in the ear with the suppressed HPs even at times.
You do have to pick and choose/pass shots. Obviously.
When it is a situation that HAS to be taken, then I step up, but more than most. Generally to some kind of 300 mag at a minimum with a good stout bullet. Its pretty rare that I feel the need to HAVE to shoot on any given day, regardless size of animal either...
