Or even on thicker-skinned game. I have two friends who've killed Cape buffalo using .375 H&H's loaded with 260-grain .375 AccuBonds. One of the buffalo was a cow, but the other was a charging bull--which was not wounded beforehand. Neither had any problem, even with frontal shots on the bull.

“Montana seems to me to be what a small boy would think Texas is like from hearing Texans.”
John Steinbeck