With 308, 7x57, 270 size cartridges using H4895 and VARGET at or below the 50% level I have often encountered the lack of complete ignition leaving kernels of powder in the bore and chamber after case extraction, at least with cast bullets. This may not be an issue with jacketed bullets.
I've had much success with AL-8 and reduced jacketed bullet loads. It was suggested that "Blue-dot data can be used" but since no one had experience with it I ventured out on my own. Keeping it in the 60-70% vicinity I have been able to duplicate much of Seafire's blue-dot data. Accuracy isn't always there with certain combinations, but when it is it sure is nice to have an accurate mild load to play with.
4198 is one of my favorites in the 06 family as well. My Whelen with exceed 250 gr factory velocities by more than 100 fps with a 260 gr pure lead slug with that powder. Haven't killed anything but rocks with it but it does a fine job at that out to 450 yards.
