I dont know why the 50AE would be a pain to reload or any different than a 45 ACP in a revolver; I suppose its a smaller diameter jacketed design creating the promblem along with a taper crimp.
A snug throat fit caster with a nice deep cannelure ought to fix the crimp issues, especially in a wheelgun. A roll, profile or a LEE Factory crimp die should work, while still allowing headspace off of the case mouth, especially if the bullet is snug in the throat. Taper crimps should too.
Have you loaded .50AE for a revolver? I have, and I'd rather ditch the 50AE and have a cylinder fitted by Magnum Research for .500 JRH, a much better chambering IMHO as you can ROLL crimp the chit out of it and not worry about head-spacing. YMMV.
