Interesting post, bison even! Let me take a contrary view just to provoke some discussion.

I would be more interested in reading (about effective NA hunting loads with various caliber 458 using jacketed bullets. When I read :"negligible waste of meat" I am thinking of bullets that just pass through with minimal killing effect. I would rather destroy some meat and drop game in their tracks. Imagine a 4,000 ft-lbs energy dump per shot! I do shoot a fair amount of cast, mostly in black powder ctg rfiles and generally not hunting,. I dont image there is much advantage in the added 200f-300 fps shooting cast. That is speculation on my part, I toss this back to the OP.