Gunner,
There are some great powders available today and the best variety of bullets the .458 ever had, so for me it is the best time in the .458's history to take it out of the safe and use it on everything from pet eradication through to medium and larger game in the interests of both proficiency and also just plain fun.

Also, there is a company called Pro-Loading in Stevensville Montana that is selling Barnes TSX .458 bullets in both 350gn and 450gn for just $22 per 100.
That is not a typo.
John

When truth is ignored, it does not change an untruth from remaining a lie.