Couldn't tell ya...………….
I have more experience with the 5mm Rem Rim Mag than the .22 Mag. I do know that the Aguila 5mm half-jacket HP (2400-2450 fps) stops expanding somewhere inside the range at which I can hit woodchucks. Now, it'll still kill them with a ribcage hit. But woodchucks ain't coyotes. I'd not hesitate to shoot a coyote 150 yards or so. But much farther, I think a good tracking snow and lots of spare time would be in order.
