Dunno...... Have shot 'chucks to a whisker under 300 with the 5mm. The .22 Mag doesn't shoot as flat. But a coyote is a substantially fatter target than a groundhog. If he'll stand still, I'll run a coyote in the ribs at 300 with one of my 5's. But it'd be like using an FMJ in the 5mm. The V-Max load for the .22 Mag drops under 1000 fps right at 200 yards. I'm guessing it's running outta gas to reliably be used on coyotes right in there somewhere.