Much more accoutrement out there for the .44 bore; of course I've never owned or fired a .41 mag, but Dad did have a Colt DA in .41lc which is actually a true .38....

Unless you are just die-hard S&W guy, the Ruger SRH Toklat in .454 Casull is an all-around superior firearm versus an N frame (of which I own couple of each). Just too lazy to unload all the Smiths.

Actually the .480 Ruger trumps them all if you cast your own bullets.
I found I can shoot the 7-1/2" Casull more accurately than the N frames on double-action. Pretty easy to do a spring job on a Ruger...
Integral scope mount is also a plus. Toklat is just a bit easier to carry if you're under 6' and don't want a chest holster.

The .460 S&W is a great choice too, but pretty heavy and awkward looking. The Super Redhawks are very fine out of the box.
Very versatile. The Casull has the velocity, the .480 offers more bullet weight and diameter. Both trump velocity in my book.