Haven't used any brand of progressive but Dillon. I used to shoot enough that I had a pair of 550's, one set up for small primer and one large, mainly because it's a PITA to change over the primer feed and get it running smoothly again. 300 rounds per hour is an easy relaxed pace on the 550, and the Dillon powder bar gets along with Unique pretty okay, though Universal meters better.
Cheyenne (and, as much as I hate to admit, 'Flave too) makes great points about caliber changes, it's not a drill I'd want to do for 4 different cartridges every Saturday. My large primer setup turned out 45 ACP on a continuous basis, with the small primer job filling an ammo can with 38 Special a few times a year. If you've got enough brass I'd go the ammo can route and stagger the caliber changes by week or month as needed.
